PREVIEW: 49ers vs Seahawks Week 1 | Shanahan vs McDonald, Purdy’s Record & CMC’s Return
Description
The San Francisco 49ers open their 2025 NFL season with a massive Week 1 showdown against the Seattle Seahawks! Can Kyle Shanahan finally solve Mike MacDonald’s Fangio-style defense after going 1-2 all-time? Brock Purdy has owned Seattle (4-1 record, 3-0 at Lumen Field), but will Christian McCaffrey’s return spark the offense against a tough Seahawks front? We also break down George Kittle’s dominance vs. Seattle, the WR room without a fully healthy Jauan Jennings, and the young 49ers defensive line needing to step up. Plus — how will the 49ers secondary handle Jaxon Smith-Njigba and Seattle’s new-look offense without DK Metcalf?
This is the ultimate 49ers vs Seahawks Week 1 preview — matchups, keys to victory, and what to expect in the first NFC West battle of the season.
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